Thalidomide Babies: Management of Limb Defects
نویسندگان
چکیده
منابع مشابه
Ocular Defects in Thalidomide Babies.
IN the early reports on congenital abnormalities in thalidomide babies in Great Britain little attention has been paid to the occurrence of ocular defects. A recent survey by the Chief Medical Officer of the Ministry of Health relating to children born with congenital limb deformities during 1960-62, revealed that there were 652 surviving children with such deformities, 244 of whose mothers had...
متن کاملThalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation.
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide are unclear. Here we demonstrate that loss of immature blood vessels is the primary cause of thalidomide-induced teratogenesis and provide an explanation for its action at the cell biological level. Antiangiogenic but ...
متن کاملRecognition of thalidomide defects.
Thalidomide: a brief history Thalidomide (alpha-phthalimido-glutarimide) was developed by the German firm Chemie Grunenthal as an anticonvulsant drug. Early trials showed it to be unsuitable for this purpose but indicated that it had sedative properties. Furthermore, it had one remarkable property: overdoses simply caused prolonged sleep, not death. The drug was first marketed in Germany in 195...
متن کاملThalidomide Embryopathy and Limb Defects; Esperiences in Habilitation of Children with Ectromelias.
Abnormalities oflimbs have been seen occasionally at all times. Thalidomide-embryopathy, however, has produced special types of defects of the extremities, which in variety and above all in numbers has made necessary the provision of special centres for treatment. At the Dept. of Paediatric Surgery and Orthopaedics of the University Children's Hospital, Munich, we observed from January 1959 to ...
متن کاملBeyond Thalidomide - Birth Defects Explained
This book will appeal to the student of medical history and would be of interest to those entering general practice to obtain some insight into how their specialty evolved in modern times. The book is well written and scholarly and gives the reader a real sense of the evolutionary processes affecting general practice in the mid twentieth century with the foundation of the College of General Pra...
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ژورنال
عنوان ژورنال: BMJ
سال: 1962
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5305.647